Description of Methamphetamine
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug referred to as crank, crystal, crystal meth, ice, and speed.
Methamphetamine is an amphetamine with central nervous system (CNS) stimulating activity. However,it acts by both facilitating the release of catecholamines, particularly noradrenaline, dopamine and serotonin, from nerve terminals in the brain and by inhibiting their uptake. This leads to an increase in synaptic concentration of these neurotransmitters and results in increased stimulation of postsynaptic receptors.
Methamphetamine is a member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent. It has a role as a neurotoxin, a psychotropic drug, a central nervous system stimulant, a xenobiotic and an environmental contaminant. It is a member of amphetamines and a secondary amine. It derives from a (S)-amphetamine. It is a conjugate base of a methamphetamine(1+).
Chemical & Physical Properties
Methamphetamine base is a colourless volatile oil insoluble in water. The most common salt is the hydrochloride (CAS-51-57-0), which occurs as a white or off-white powder or as crystals soluble in water.
Illicit products mostly consist of powders, but the pure crystalline hydrochloride is known as 'ice'. Tablets containing methamphetamine may carry logos similar to those seen on MDMA and other ecstasy tablets.Also, it has a bitter taste.
Mode of use
Methamphetamine may be ingested, snorted and, less commonly, injected or smoked. Unlike the sulfate salt of amphetamine, methamphetamine hydrochloride, particularly the crystalline form (ice), is sufficiently volatile to be smoked.
When ingested, a dose may vary from several tens to several hundreds of milligrams depending on the purity and the isomeric composition.