Description of JWH018
1-Pentyl-3-(1-naphthoyl)indole (also called AM-678 and JWH-018) is a full agonist synthetic cannabinoid first synthesized by organic chemist John W. Huffman. It gained popularity in late 2008 when German chemists found it as a chemical within the popular synthetic cannabis blend Spice, which had been sold in numerous countries around the world since 2002.
Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. JWH-018 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.
JWH-018 is an aminoalkylindole used as an active ingredient of products sold as cannabis substitutes. When smoked, JWH-018 produces cannabimimetic effects in doses lower than the doses of Δ9-tetrahydrocannabinol (THC) needed to produce effects of similar strength (higher potency).
Routes of administration and dosageJWH-018 is mainly offered on the Internet either in the form of ‘herbal mixtures’,where the chemical has been sprayed on plant material (e.g. damiana), or as a powder. Based on user reports and on the dosage forms offered, the primary route of administration is inhalation either by smoking the ‘herbal mixture’ as a joint or utilizing a vaporizer, bong or pipe.
Furthermore, oral consumption of the compound was described by various users on the Internet. Based on information posted at Internet for a, common dosages are in the range of 2 to 5 mg when smoked/vaporized (erowid.org). Doses for oral application can be assumed to be significantly higher due to lower bioavailability (first pass effect). Reports suggest a duration of action for JWH-018 of approximately 1-2 hours when smoked.
Effects of JWH018-Spontaneous physical sensations
-Perception of bodily lightness
-Changes in felt gravity
-Increased music appreciation