2C-I is a psychedelic drug that is a phenethylamine, or an organic compound that acts as a nervous system stimulant. The 2C-I drug gained the nickname smiles because, unlike many psychedelic drugs, 2C-I has effects similar to MDMA (ecstasy).
2C-I was synthesized by Alexander Shulgin in 1975, along with some other phenethylamines and the rest of the 2C-I drugs. He published a study measuring the potency of these drugs and later a book titled PiHKAL: A Chemical Love Story.
Shulgin is credited with introducing MDMA to the scientific community and through his work became known as the “godfather of psychedelics”. In his published writings, he describes a plethora of different chemical compounds with slight variations and varied effects.
2C-I is often confused with the drug 2C-I-NBOMe which is a psychedelic that also shares some effects similar to MDMA. However, this drug, also known as “smiles,” has a much lower active dose than NBOMe. It has lead to overdoses when users take a dose that would be appropriate for 2C-I.
Physiological Experience Of 2C-ISince the 2C-I drug is a stimulant, it causes a variety of effects that manifest in the body including muscle spasm, cramps, and contractions. In a 2014 study, researchers found that the drug produced a head twitch in mice.
The drug has other physical effects that aren’t typical of other psychedelics like DMT or psilocybin. For instance, 2C-1 drug effects raise energy levels in a way that is similar to MDMA. 2C-I is also said to produce an intense “body high”, or pins and needles and skin sensitivity, in a larger dosage that isn’t present in other psychedelics.
Users also experience unpredictable rushes of bodily warmth that start at the top of the head. Others who experience this kind of physical euphoria may also feel an intensification of the sense of touch.